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Article

EGFR plays a pivotal role in the regulation of polyamine-dependent apoptosis in intestinal epithelial cells.

Cellular signalling - 1 Dec 2007

Ray Ramesh M, Bhattacharya Sujoy, Johnson Leonard R

Abstract excerpt

Intracellular polyamine synthesis is regulated by the enzyme ornithine decarboxylase (ODC), and its inhibition by alpha-difluromethylornithine (DFMO), confers resistance to apoptosis. We have previously shown that DFMO leads to the inhibition of de novo polyamine synthesis, which in turn rapidly...

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Source

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Identifiers

PMID: 17825525
DOI: 10.1016/j.cellsig.2007.08.001
PMCID: PMC2699668

Genes

EGFR
EGF
STAT3
TNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17825525-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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