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Article

Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2.

The Journal of biological chemistry - 27 Aug 2004

Anthony Tracy G, McDaniel Brent J, Byerley Rachel L, McGrath Barbara C, Cavener Douglas R, McNurlan Margaret A, Wek Ronald C

Abstract excerpt

In eukaryotic cells, amino acid depletion reduces translation by a mechanism involving phosphorylation of eukaryotic initiation factor-2 (eIF2). Herein we describe that mice lacking the eIF2 kinase, general control nonderepressible 2 (GCN2) fail to alter the phosphorylation of this initiation fac...

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Identifiers

PMID: 15213227
DOI: 10.1074/jbc.M404559200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15213227-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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