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Article

GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase.

The Journal of biological chemistry - 20 Nov 2009

Bunpo Piyawan, Dudley Allison, Cundiff Judy K, Cavener Douglas R, Wek Ronald C, Anthony Tracy G

Abstract excerpt

Asparaginase depletes circulating asparagine and glutamine, activating amino acid deprivation responses (AADR) such as phosphorylation of eukaryotic initiation factor 2 (p-eIF2) leading to increased mRNA levels of asparagine synthetase and CCAAT/enhancer-binding protein beta homologous protein (C...

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Identifiers

PMID: 19783659
DOI: 10.1074/jbc.M109.047910
PMCID: PMC2781691

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19783659-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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