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Article

Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses.

The EMBO journal - 19 Apr 2006

Berlanga Juan J, Ventoso Iván, Harding Heather P, Deng Jing, Ron David, Sonenberg Nahum, Carrasco Luis, de Haro César

Abstract excerpt

In mammals, four different protein kinases, heme-regulated inhibitor, double-stranded RNA-dependent protein kinase (PKR), general control non-derepressible-2 (GCN2) and PKR-like endoplasmic reticulum kinase, regulate protein synthesis in response to environmental stresses by phosphorylating the a...

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Identifiers

PMID: 16601681
DOI: 10.1038/sj.emboj.7601073
PMCID: PMC1440839

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16601681-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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