The Effect of Long Term Calorie Restriction on in Vivo Hepatic Proteostatis: A Novel Combination of Dynamic and Quantitative Proteomics

Abstract excerpt

Calorie restriction (CR) promotes longevity. A prevalent mechanistic hypothesis explaining this effect suggests that protein degradation, including mitochondrial autophagy, is increased with CR, removing damaged proteins and improving cellular fitness. At steady state, increased catabolism must be balanced by increasing mitochondrial biogenesis and protein synthesis, resulting in faster protein replacement rates....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Liver Disease Diagnosis and Treatment
• Share to Liver physiology and pathology
• Share to Pancreatic function and diabetes