Article
Shorter telomeres are associated with mortality in those with APOE epsilon4 and dementia.
Annals of neurology - 1 Aug 2006
Honig Lawrence S, Schupf Nicole, Lee Joseph H, Tang Ming X, Mayeux Richard
Abstract excerpt
OBJECTIVE: Reduced telomere length may be a marker of biological aging. We hypothesized that telomere length might thus relate to increased risk for dementia and mortality. METHODS: This nested case-control study used stored leukocyte DNA from 257 individuals (mean age, 81.4 +/- 7.9 years; 64.6% female; 44.7% Hispanic, 33.5% non-Hispanic black, and 21.8% non-Hispanic white). Our assay used real-time polymerase...
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