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Article

Egr-2 and Egr-3 are negative regulators of T cell activation.

Nature immunology - 1 May 2005

Safford Meredith, Collins Samuel, Lutz Michael A, Allen Amy, Huang Ching-Tai, Kowalski Jeanne, Blackford Amanda, Horton Maureen R, Drake Charles, Schwartz Ronald H, Powell Jonathan D

Abstract excerpt

T cell receptor engagement in the absence of proper accessory signals leads to T cell anergy. E3 ligases are involved in maintaining the anergic state. However, the specific molecules responsible for the induction of anergy have yet to be elucidated. Using microarray analysis we have identified here early growth response gene 2 (Egr-2) and Egr-3 as key negative regulators of T cell activation. Overexpression of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15834410
DOI: 10.1038/ni1193

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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