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Article

The function of the small insertion in the hinge subdomain in the control of constitutive mammalian nitric-oxide synthases.

The Journal of biological chemistry - 27 Aug 2004

Jones Rachel J, Smith Susan M E, Gao Ying Tong, DeMay Bradley S, Mann Kevin J, Salerno Kathleen M, Salerno John C

Abstract excerpt

Control of nitric oxide (NO) synthesis in the constitutive nitric-oxide synthases (NOS) by calcium/calmodulin is exerted through the regulation of electron transfer from NADPH through the reductase domains. This process has been shown previously to involve the calmodulin binding site, the autoinhibitory insertion in the FMN binding domain, and the C-terminal tail. Smaller sequence elements also appear to...

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Share to Adenosine Diphosphate
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15210721
DOI: 10.1074/jbc.M402808200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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