Article
The angiotensin-converting enzyme insertion/deletion polymorphism is associated with phagocytic NADPH oxidase-dependent superoxide generation: potential implication in hypertension.
Clinical science (London, England : 1979) - 1 Feb 2009
San José Gorka, Fortuño Ana, Moreno María U, Robador Pablo A, Bidegain Julen, Varo Nerea, Beloqui Oscar, Díez Javier, Zalba Guillermo
Abstract excerpt
The objective of the present study was to analyse the influence of the ACE (angiotensin-converting enzyme) gene I/D (insertion/deletion) polymorphism on NADPH oxidase-dependent O(2)(*-) (superoxide radical) production, and to investigate the clinical implication of this association in hypertensive subjects. A case-control study was performed in a random sample of the general population composed of 189...
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