Article
[Environmental carcinogens and p53 gene mutation].
Wei sheng yan jiu = Journal of hygiene research - 1 Mar 2004
Xu Zhen, Jin Yinlong
Abstract excerpt
P53 gene is the most prominent tumor suppressor gene in human cancer among those genes that have been found till now. It not only acts as a tumor suppressor gene, but also participates in many cellular functions: cell cycle control, DNA damage and repair, gene transcription and cell apoptosis. The studies on the etiology of cancer show that 60-90% of human cancer are caused by the carcinogens in ambient...
Topics
- Aflatoxin B1
- Animals
- Benzo(a)pyrene
- Carcinogens, Environmental
- Genes, p53
- Humans
- Mutation
- Neoplasms
- Tumor Suppressor Protein p53
