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Article

Inhibition of growth and invasive ability of melanoma by inactivation of mutated BRAF with lentivirus-mediated RNA interference.

Oncogene - 12 Aug 2004

Sumimoto Hidetoshi, Miyagishi Makoto, Miyoshi Hiroyuki, Yamagata Shizuko, Shimizu Ayako, Taira Kazunari, Kawakami Yutaka

Abstract excerpt

Oncogenic mutations of molecules involved in the mitogen-activated protein kinase (MAPK) pathways provide signals mediating both tumor growth and invasion in various cancers including melanomas. BRAF somatic mutations, found in 66% of melanomas, have NIH3T3 transforming ability with the elevated kinase activity in vitro. We attempted to mediate RNA interference (RNAi) with HIV lentiviral vectors specific for...

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Source

Identifiers

PMID: 15208655
DOI: 10.1038/sj.onc.1207812

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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