Article
Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors.
Cancer research - 15 Mar 2005
Sharma Arati, Trivedi Nishit R, Zimmerman Melissa A, Tuveson David A, Smith Charles D, Robertson Gavin P
Abstract excerpt
Activating mutations of the B-RAF gene are observed in >60% of human melanomas. Approximately 90% of these mutations occur in the activation segment of the kinase domain as a single-base substitution that converts a valine to glutamic acid at codon 599 (V599E) in exon 15. This mutation causes activation of the kinase as well as downstream effectors of the mitogen-activated protein kinase-signaling cascade,...
Topics
- Animals
- Apoptosis
- Benzenesulfonates
- Cell Growth Processes
- Cell Line, Tumor
- Humans
- MAP Kinase Signaling System
- Melanoma
- Mice
- Mutation
- Neovascularization, Pathologic
- Niacinamide
- Phenylurea Compounds
- Proto-Oncogene Proteins B-raf
- Pyridines
- RNA, Small Interfering
- Sorafenib
- Vascular Endothelial Growth Factor A