Article
Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors.
Cancer research - 15 Mar 2005
Sharma Arati, Trivedi Nishit R, Zimmerman Melissa A, Tuveson David A, Smith Charles D, Robertson Gavin P
Abstract excerpt
Activating mutations of the B-RAF gene are observed in >60% of human melanomas. Approximately 90% of these mutations occur in the activation segment of the kinase domain as a single-base substitution that converts a valine to glutamic acid at codon 599 (V599E) in exon 15. This mutation causes activation of the kinase as well as downstream effectors of the mitogen-activated protein kinase-signaling cascade,...
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