Article
Sensitivity of Melanoma Cells to EGFR and FGFR Activation but Not Inhibition is Influenced by Oncogenic BRAF and NRAS Mutations.
Pathology oncology research : POR - 1 Sept 2015
Garay Tamás, Molnár Eszter, Juhász Éva, László Viktória, Barbai Tamás, Dobos Judit, Schelch Karin, Pirker Christine, Grusch Michael, Berger Walter, Tímár József, Hegedűs Balázs
Abstract excerpt
BRAF and NRAS are the two most frequent oncogenic driver mutations in melanoma and are pivotal components of both the EGF and FGF signaling network. Accordingly, we investigated the effect of BRAF and NRAS oncogenic mutation on the response to the stimulation and inhibition of epidermal and fibroblast growth factor receptors in melanoma cells. In the three BRAF mutant, two NRAS mutant and two double wild-type...
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