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Article

Activation of Ras-Ral pathway attenuates p53-independent DNA damage G2 checkpoint.

The Journal of biological chemistry - 27 Aug 2004

Agapova Larissa S, Volodina Julia L, Chumakov Peter M, Kopnin Boris P

Abstract excerpt

Earlier we have found that in p53-deficient cells the expression of activated Ras attenuates the DNA damage-induced arrest in G(1) and G(2). In the present work we studied Ras-mediated effects on the G(2) checkpoint in two human cell lines, MDAH041 immortalized fibroblasts and Saos-2 osteosarcoma cells. The transduction of the H-Ras mutants that retain certain functions (V12S35, V12G37, and V12C40 retain the...

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Identifiers

PMID: 15208305
DOI: 10.1074/jbc.M405007200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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