Article
The involvement of sequence variation and expression of CX3CR1 in the pathogenesis of age-related macular degeneration.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2004
Tuo Jingsheng, Smith Brena C, Bojanowski Christine M, Meleth Annal D, Gery Igal, Csaky Karl G, Chew Emily Y, Chan Chi-Chao
Abstract excerpt
This study examined the association between the sequence variation/expression of CX3CR1, a chemokine receptor, and age-related macular degeneration (AMD). Peripheral blood from 85 AMD patients and 105 subjects without AMD (controls), as well as ocular tissue from 40 pathological sections with AMD and two normal eye sections, were screened for V249I and T280M, two single nucleotide polymorphisms (SNPs) in CX3CR1....
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