Article
Detection of CX3CR1 single nucleotide polymorphism and expression on archived eyes with age-related macular degeneration.
Histology and histopathology - 1 Jul 2005
Chan C-C, Tuo J, Bojanowski C M, Csaky K G, Green W R
Abstract excerpt
There is a significant genetic component in age-related macular degeneration (AMD). CX3CR1, which encodes the fractalkine (chemokine, CX3CL1) receptor, has two single nucleotide polymorphisms (SNPs): V249I and T280M. These SNPs are correlated with other aged-related diseases such as atherosclerosis. We have reported an association of CX3CR1 SNP and AMD. In this study we examined CX3CR1 SNP frequencies and protein...
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