Article
Mechanism for induction of adaptive mutations in Escherichia coli.
Molecular microbiology - 1 Apr 1990
Boe L
Abstract excerpt
When bacterial cells are subjected to a strong selective pressure it often induces specific mutations. Here a model is considered in which errors are introduced at random in one of the strands of the DNA molecule: a nick in one of the strands can initiate strand displacement rendering a region of the chromosome single-stranded. Upon conversion back to double-stranded DNA there is a certain probability of...
Topics
- Adaptation, Physiological
- DNA Replication
- DNA, Bacterial
- DNA-Directed DNA Polymerase
- Escherichia coli
- Methylation
- Models, Molecular
- Mutation
- RNA, Messenger