Article
SOS mutator DNA polymerase IV functions in adaptive mutation and not adaptive amplification.
Molecular cell - 1 Mar 2001
McKenzie G J, Lee P L, Lombardo M J, Hastings P J, Rosenberg S M
Abstract excerpt
Adaptive point mutation and amplification are induced responses to environmental stress, promoting genetic changes that can enhance survival. A specialized adaptive mutation mechanism has been documented in one Escherichia coli assay, but its enzymatic basis remained unclear. We report that the SOS-inducible, error-prone DNA polymerase (pol) IV, encoded by dinB, is required for adaptive point mutation in the E....
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