Article
Impact of a stress-inducible switch to mutagenic repair of DNA breaks on mutation in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America - 16 Aug 2011
Shee Chandan, Gibson Janet L, Darrow Michele C, Gonzalez Caleb, Rosenberg Susan M
Abstract excerpt
Basic ideas about the constancy and randomness of mutagenesis that drives evolution were challenged by the discovery of mutation pathways activated by stress responses. These pathways could promote evolution specifically when cells are maladapted to their environment (i.e., are stressed). However, the clearest example--a general stress-response-controlled switch to error-prone DNA break (double-strand break, DSB)...
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