Article
The transmembrane protein Off-track associates with Plexins and functions downstream of Semaphorin signaling during axon guidance.
Neuron - 11 Oct 2001
Winberg M L, Tamagnone L, Bai J, Comoglio P M, Montell D, Goodman C S
Abstract excerpt
The Plexin family of transmembrane proteins appears to function as repulsive receptors for most if not all Semaphorins. Here, we use genetic and biochemical analysis in Drosophila to show that the transmembrane protein Off-track (OTK) associates with Plexin A, the receptor for Sema 1a, and that OTK is a component of the repulsive signaling response to Semaphorin ligands. In vitro, OTK associates with Plexins. In...
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