Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence of genetic interaction between the beta-globin complex and chromosome 8q in the expression of fetal hemoglobin.

American journal of human genetics - 1 Mar 2002

Garner Chad P, Tatu Thanusak, Best Steve, Creary Lisa, Thein Swee Lay

Abstract excerpt

During human development, the switch from fetal to adult hemoglobin (Hb) is not complete with the residual gamma-globin expression being restricted to a subset of erythrocytes termed "F cells" (FC). Statistical analyses have shown the FC trait to be influenced by a common sequence variant (C-->T) at position -158 upstream of the Ggamma-globin gene, termed the "XmnI-Ggamma polymorphism." The XmnI-Ggamma site is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 8
Share to Fetal Hemoglobin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Genetic Markers

Share to Globins

Share to Lod Score

Share to Probability

Share to Quantitative Trait, Heritable

Source

Open in PubMed Open full text

Identifiers

PMID: 11822023
DOI: 10.1086/339248
PMCID: PMC384958

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence of genetic interaction between the beta-globin complex and chromosome 8q in the expression of fetal hemoglobin.PMID 11822023Read ↗

Quantitative trait locus on chromosome 8q influences the switch from fetal to adult hemoglobin.Semantic proximity Read ↗

Interaction between two quantitative trait loci affects fetal haemoglobin expression.Semantic proximity Read ↗

Influences of genetic variation on fetal hemoglobin.Semantic proximity Read ↗

Control of fetal hemoglobin: new insights emerging from genomics and clinical implications.Semantic proximity Read ↗

Mechanisms of Globin Gene Regulation in MammalsSemantic proximity Read ↗

Chromatin Structure and Control of β-Like Globin Gene SwitchingSemantic proximity Read ↗

Regulation of human fetal hemoglobin: new players, new complexitiesSemantic proximity Read ↗

Dissecting the loci controlling fetal haemoglobin production on chromosomes 11p and 6q by the regressive approachSemantic proximity Read ↗

Haplotype mapping of a major quantitative-trait locus for fetal hemoglobin production, on chromosome 6q23.Semantic proximity Read ↗

The 5' regulatory region of the human fetal globin genes is a gene conversion hotspot.Semantic proximity Read ↗

Activation of γ-globin expression by a common variant disrupting IKAROS-binding motif in β-thalassemia.Semantic proximity Read ↗

Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.