Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GPx-1 modulates Akt and P70S6K phosphorylation and Gadd45 levels in MCF-7 cells.

Free radical biology & medicine - 15 Jul 2004

Nasr Mohamed A, Fedele Mark J, Esser Karyn, Diamond Alan M

Abstract excerpt

Selenium has been shown to prevent cancer in animal models, and recent data indicate it is likely to be effective in humans as well. One selenium-containing protein, the cytoplasmic form of glutathione peroxidase (GPx-1), has been implicated in cancer risk and development by genetic studies identifying at-risk alleles and loss of heterozygosity in tumors. In order to evaluate the biological consequences of GPx-1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Free Radicals
Share to Glutathione Peroxidase
Share to Glutathione Peroxidase GPX1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitogen-Activated Protein Kinase 1

Share to Mitogen-Activated Protein Kinase 3

Share to p38 Mitogen-Activated Protein Kinases

Share to Ribosomal Protein S6 Kinases, 70-kDa

Share to Selenium

Source

Identifiers

PMID: 15203190
DOI: 10.1016/j.freeradbiomed.2004.04.038

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GPx-1 modulates Akt and P70S6K phosphorylation and Gadd45 levels in MCF-7 cells.PMID 15203190Read ↗

Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities.Semantic proximity Read ↗

Molecular consequences of genetic variations in the glutathione peroxidase 1 selenoenzyme.Semantic proximity Read ↗

GPx-1 polymorphism (rs1050450) contributes to tumor susceptibility: evidence from meta-analysis.Semantic proximity Read ↗

Lipid peroxidation and glutathione peroxidase activity relationship in breast cancer depends on functional polymorphism of GPX1.Semantic proximity Read ↗

Allele-specific interaction between glutathione peroxidase 1 and manganese superoxide dismutase affects the levels of Bcl-2, Sirt3 and E-cadherin.Semantic proximity Read ↗

Dietary selenium deficiency partially rescues type 2 diabetes-like phenotypes of glutathione peroxidase-1-overexpressing male mice.Semantic proximity Read ↗

Selenoprotein deficiency enhances radiation‐induced micronuclei formationSemantic proximity Read ↗

Genetic variation in GPX1 is associated with GPX1 activity in a comprehensive analysis of genetic variations in selenoenzyme genes and their activity and oxidative stress in humans.Semantic proximity Read ↗

Natural allelic variations in glutathione peroxidase-1 affect its subcellular localization and function.Semantic proximity Read ↗

Effects of selenium status and polymorphisms in selenoprotein genes on prostate cancer risk in a prospective study of European men.Semantic proximity Read ↗

DNA damage and oxidative stress response to selenium yeast in the non-smoking individuals: a short-term supplementation trial with respect to GPX1 and SEPP1 polymorphism.Semantic proximity Read ↗

Epididymal specific, selenium-independent GPX5 protects cells from oxidative stress-induced lipid peroxidation and DNA mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.