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Article

Noncatalytic requirement for cyclin A-cdk2 in p27 turnover.

Molecular and cellular biology - 1 Jul 2004

Zhu Xin-Hua, Nguyen Hoang, Halicka H Dorota, Traganos Frank, Koff Andrew

Abstract excerpt

Ubiquitin-dependent proteolysis makes a major contribution to decreasing the levels of p27. Ubiquitin-dependent proteolysis of p27(kip1) is growth and cell cycle regulated in two ways: first, skp2, a component of the E3-ubiquitin ligase, is growth regulated, and second, a kinase must phosphorylate the threonine-187 position on p27 so that it can be recognized by skp2. In vitro, p27 is phosphorylated by cyclin E-...

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Share to Cyclin A
Share to CDC2-CDC28 Kinases
Share to Cyclin-Dependent Kinase 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p27

Share to Cyclin E

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Source

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Identifiers

PMID: 15199159
DOI: 10.1128/MCB.24.13.6058-6066.2004
PMCID: PMC480915

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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