Article
Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation.
Molecular cell - 1 Aug 2003
Welcker Markus, Singer Jeffrey, Loeb Keith R, Grim Jonathan, Bloecher Andrew, Gurien-West Mark, Clurman Bruce E, Roberts James M
Abstract excerpt
Autophosphorylation-triggered ubiquitination has been proposed to be the major pathway regulating cyclin E protein abundance: phosphorylation of cyclin E on T380 by its associated CDK allows binding to the receptor subunit, Fbw7, of the SCFFbw7 ubiquitin ligase. We have tested this model in vivo and found it to be an inadequate representation of the pathways that regulate cyclin E degradation. We show that...
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