Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Altered expression of transcription factor Sp1 critically impacts the angiogenic phenotype of human gastric cancer.

Clinical & experimental metastasis - 1 Jan 2005

Wang Liwei, Guan Xiaohong, Gong Weida, Yao James, Peng Zhihai, Wei Daoyan, Wu Tsung-Teh, Huang Suyun, Xie Keping

Abstract excerpt

Our recent study has shown that transcription factor Sp1 is an independent prognostic factor in gastric cancer. However, it is unclear how Sp1 impacts gastric cancer biology. Since Sp1 regulates multiple genes important to angiogenesis, we sought to evaluate the relationship between Sp1 expression and microvessel density (MVD) as well as their effects on cancer patient survival. The expression of Sp1 and status...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to In Vitro Techniques
Share to Mice, Nude

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasm Metastasis

Share to Neoplasm Transplantation

Share to Neovascularization, Pathologic

Share to Sp1 Transcription Factor

Share to Stomach Neoplasms

Share to Survival Rate

Source

Identifiers

PMID: 16158248
DOI: 10.1007/s10585-005-5684-3

Genes

MVD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Altered expression of transcription factor Sp1 critically impacts the angiogenic phenotype of human gastric cancer.PMID 16158248Read ↗

Association between Expression of Transcription Factor Sp1 and Increased Vascular Endothelial Growth Factor Expression, Advanced Stage, and Poor Survival in Patients with Resected Gastric CancerSemantic proximity Read ↗

Role of Sp1 expression in gastric cancer: A meta‑analysis and bioinformatics analysisSemantic proximity Read ↗

Pan-cancer analysis of Sp1 with a focus on immunological roles in gastric cancerSemantic proximity Read ↗

Expression of endothelial nitric oxide synthase correlates with the angiogenic phenotype of and predicts poor prognosis in human gastric cancer.Semantic proximity Read ↗

Transcription Factor Sp1 in the Expression of Genes Encoding Components of Mapk, JAK/STAT, and PI3K/Akt Signaling PathwaysSemantic proximity Read ↗

Role of hypoxia-inducible factor 1alpha in gastric cancer cell growth, angiogenesis, and vessel maturation.Semantic proximity Read ↗

Constitutive phosphorylation of the FOXO1 transcription factor in gastric cancer cells correlates with microvessel area and the expressions of angiogenesis-related moleculesSemantic proximity Read ↗

hTERT promotes tumor angiogenesis by activating VEGF via interactions with the Sp1 transcription factorSemantic proximity Read ↗

Helicobacter pylori stimulates host vascular endothelial growth factor‐A ( vegf‐A ) gene expression via MEK/ERK‐dependent activation of Sp1 and Sp3Semantic proximity Read ↗

The significance of placenta growth factor in angiogenesis and clinical outcome of human gastric cancerSemantic proximity Read ↗

Dysregulated Sp1/miR-130b-3p/HOXA5 axis contributes to tumor angiogenesis and progression of hepatocellular carcinomaSemantic proximity Read ↗

Decreased Sp1 Expression Mediates Downregulation of SHIP2 in Gastric Cancer Cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.