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Article

Neurotoxic mechanisms by Alzheimer's disease-linked N141I mutant presenilin 2.

The Journal of pharmacology and experimental therapeutics - 1 Mar 2002

Hashimoto Yuichi, Niikura Takako, Ito Yuko, Kita Yoshiko, Terashita Kenzo, Nishimoto Ikuo

Abstract excerpt

Although it has been established that oxidative stress mediates cytotoxicity by familial Alzheimer's disease (FAD)-linked mutants of presenilin (PS)1 and that pertussis toxin inhibits cytotoxicity by FAD-linked N141I-PS2, it has not been determined whether oxidative stress is involved in cytotoxicity by N141I-PS2 or which pertussis toxin-sensitive proteins mediate the cytotoxicity. Here we report that low...

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Identifiers

PMID: 11861776
DOI: 10.1124/jpet.300.3.736

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Neurotoxic mechanisms by Alzheimer's disease-linked N141I mutant presenilin 2.PMID 11861776Read ↗

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