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Article

Losartan hydroxylation phenotype in an Ecuadorian population: influence of CYP2C9 genetic polymorphism, habits and gender.

Pharmacogenomics - 1 Nov 2012

Dorado Pedro, Beltrán Leonardo J, Machín Esther, Peñas-Lledó Eva M, Terán Enrique, Llerena Adrián

Abstract excerpt

AIM: To describe for the first time CYP2C9 hydroxylation phenotype with CYP2C9 genotypes in a Hispanic (Ecuadorian) population using losartan; and the relevance of gender, tobacco, ethanol and caffeine consumption on the enzyme hydroxylation capacity. METHODS: Ecuadorian healthy volunteers (n = 194) received a single oral dose of 25 mg losartan. Losartan metabolic ratio was defined as losartan:E3174...

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Source

Identifiers

PMID: 23171336
DOI: 10.2217/pgs.12.160

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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