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Article

CYP2C9 genotype modifies activity of the renin-angiotensin-aldosterone system in hypertensive men.

Journal of hypertension - 1 Oct 2009

Donner Kati M, Hiltunen Timo P, Suonsyrjä Timo, Hannila-Handelberg Tuula, Tikkanen Ilkka, Antikainen Miia, Hirvonen Ari, Kontula Kimmo

Abstract excerpt

BACKGROUND: Two variants of the CYP2C9 gene, CYP2C9*2 and CYP2C9*3, have been indicated to have impaired enzyme function, and thus suspected to reduce the formation of the active metabolite of losartan. Cytochrome P450 (CYP) enzymes are also involved in eicosanoid biosynthesis and regulation of blood pressure (BP) and sodium homeostasis. METHODS: We studied the impact of these variants on BP response to losartan...

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Identifiers

PMID: 19593208
DOI: 10.1097/HJH.0b013e32832f4fae

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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