Article
Increased liability of tramadol-warfarin interaction in individuals with mutations in the cytochrome P450 2D6 gene.
European journal of clinical pharmacology - 1 Jul 2004
Hedenmalm Karin, Lindh Jonatan D, Säwe Juliette, Rane Anders
Abstract excerpt
OBJECTIVE: This study aimed to investigate the importance of cytochrome P(450) enzymes for the reported interaction between tramadol and warfarin. MATERIALS AND METHODS: Cases of suspected interaction between tramadol and warfarin resulting in International Normalised Ratios increases that were reported to the Swedish Adverse Drug Reactions Advisory Committee until March 2003 were included. Ten cases had been...
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