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Article

Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest.

Molecular and cellular biology - 1 Feb 2004

Davies Sally L, North Phillip S, Dart Alwyn, Lakin Nicholas D, Hickson Ian D

Abstract excerpt

Bloom's syndrome (BS) is a human genetic disorder associated with cancer predisposition. The BS gene product, BLM, is a member of the RecQ helicase family, which is required for the maintenance of genome stability in all organisms. In budding and fission yeasts, loss of RecQ helicase function con...

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Source

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Identifiers

PMID: 14729972
DOI: 10.1128/MCB.24.3.1279-1291.2004
PMCID: PMC321429

Genes

BLM
ATR
RAD51

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14729972-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest.PMID 14729972Read ↗

Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrestSemantic proximity Read ↗

The Human WRN and BLM RecQ Helicases Differentially Regulate Cell Proliferation and Survival after Chemotherapeutic DNA DamageSemantic proximity Read ↗

Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrestSemantic proximity Read ↗

Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint.Semantic proximity Read ↗

Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phasesSemantic proximity Read ↗

Bloom syndrome, genomic instability and cancer: the SOS-like hypothesis.Semantic proximity Read ↗

Regulation and Localization of the Bloom Syndrome Protein in Response to DNA DamageSemantic proximity Read ↗

Bloom helicase and DNA topoisomerase IIIalpha are involved in the dissolution of sister chromatids.Semantic proximity Read ↗

Intra-nuclear trafficking of the BLM helicase to DNA damage-induced foci is regulated by SUMO modification.Semantic proximity Read ↗

Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycleSemantic proximity Read ↗

Telomere and ribosomal DNA repeats are chromosomal targets of the bloom syndrome DNA helicase.Semantic proximity Read ↗

A novel cell-cycle-regulated interaction of the Bloom syndrome helicase BLM with Mcm6 controls replication-linked processes.Semantic proximity Read ↗

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