Article
Metabolic gene polymorphisms and p53 mutations in healthy centenarians and younger controls.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals - 1 Jan 2000
Gaspari L, Pedotti P, Bonafè M, Franceschi C, Marinelli D, Mari D, Garte S, Taioli E
Abstract excerpt
To obtain insights into the genetic mechanisms of ageing, we studied the frequency of the simultaneous presence of polymorphisms in phase I and phase II genes and of several p53 germline mutations in a group of 66 nonagenarians and centenarians in good health, selected from a larger sample of a multicentre Italian study in Northern Italy, and in a sample of 150 young healthy volunteers of the same ethnic group....
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