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Article

Metabolic regulation of oxygen and redox homeostasis by p53: lessons from evolutionary biology?

Free radical biology & medicine - 15 Sept 2012

Zhuang Jie, Ma Wenzhe, Lago Cory U, Hwang Paul M

Abstract excerpt

The genetic links between p53 and metabolic processes such as oxidative phosphorylation are being studied with increasing interest given that cellular metabolism seems to play an important role in tumorigenesis. This review focuses on how p53 regulation of various metabolic genes may influence redox homeostasis, as the genome is constantly susceptible to oxidative damage, a consequence of living in an aerobic...

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Identifiers

PMID: 22841759
DOI: 10.1016/j.freeradbiomed.2012.07.026
PMCID: PMC3444283

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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