Article
Prevalence of at-risk genotypes for genotoxic effects decreases with age in a randomly selected population in Flanders: a cross sectional study.
Environmental health : a global access science source - 5 Oct 2011
Ketelslegers Hans B, Godschalk Roger W L, Gottschalk Ralph W H, Knaapen Ad M, Koppen Gudrun, Schoeters Greet, Baeyens Willy F, Nelen Vera, Geraedts Joep P M, van Delft Joost H M, Kleinjans Jos C S, van Larebeke Nicolas A
Abstract excerpt
BACKGROUND: We hypothesized that in Flanders (Belgium), the prevalence of at-risk genotypes for genotoxic effects decreases with age due to morbidity and mortality resulting from chronic diseases. Rather than polymorphisms in single genes, the interaction of multiple genetic polymorphisms in low penetrance genes involved in genotoxic effects might be of relevance. METHODS: Genotyping was performed on 399 randomly...
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