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Article

Polymorphic metabolic susceptibility genes and longevity: a study in octogonarians.

Toxicology letters - 15 Jun 2004

Pesch Beate, Düsing Rainer, Rabstein Sylvia, Harth Volker, Grentrup Dagmar, Brüning Thomas, Landt Olfert, Vetter Hans, Ko Yon-Dschun

Abstract excerpt

In order to investigate possible associations of genetic variants in genes of xenobiotic metabolism with longevity, we compared allele frequencies and genotype distributions of polymorphic genes between 205 octogenarians and a non-cancer reference group of 294 persons aged less than 80 years. We analyzed common sequence variations in the cytochrome P-450 genes CYP1A1 T461N, 3801 T > C and CYP1B1 V432L, and in the...

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Source

Identifiers

PMID: 15177664
DOI: 10.1016/j.toxlet.2004.01.025

Genes

GSTT1
GSTM1
GSTP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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