Article
BRAF mutations in colon cancer are not likely attributable to defective DNA mismatch repair.
Cancer research - 1 Sept 2003
Wang Liang, Cunningham Julie M, Winters Jennifer L, Guenther Jennifer C, French Amy J, Boardman Lisa A, Burgart Lawrence J, McDonnell Shannon K, Schaid Daniel J, Thibodeau Stephen N
Abstract excerpt
Frequent BRAF mutations were reported recently in a variety of human malignancies, including colorectal cancer. In this study, we screened 293 colorectal cancers for mutations in exons 11 and 15, two regions containing hotspots for BRAF mutation. Of the 293 cancers, 170 had normal mismatch repair, and 123 had defective mismatch repair (originating from both somatic as well as germ-line mutations in several of the...
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