Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status.

Abstract excerpt

Genes of the RAF family encode kinases that are regulated by Ras and mediate cellular responses to growth signals. Activating mutations in one RAF gene, BRAF, have been found in a high proportion of melanomas and in a small fraction of other cancers. Here we show that BRAF mutations in colorectal cancers occur only in tumours that do not carry mutations in a RAS gene known as KRAS, and that BRAF mutation is...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Oncogenes
• Share to Base Pair Mismatch
• Share to Colorectal Neoplasms