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Article

PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations.

The EMBO journal - 7 Jul 2004

Baki Lia, Shioi Junichi, Wen Paul, Shao Zhiping, Schwarzman Alexander, Gama-Sosa Miguel, Neve Rachael, Robakis Nikolaos K

Abstract excerpt

Phosphatidylinositol 3-kinase (PI3K) promotes cell survival and communication by activating its downstream effector Akt kinase. Here we show that PS1, a protein involved in familial Alzheimer's disease (FAD), promotes cell survival by activating the PI3K/Akt cell survival signaling. This function of PS1 is unaffected by gamma-secretase inhibitors. Pharmacological and genetic evidence indicates that PS1 acts...

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Identifiers

PMID: 15192701
DOI: 10.1038/sj.emboj.7600251
PMCID: PMC449766

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations.PMID 15192701Read ↗

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