Article
Formation of tau inclusions in knock-in mice with familial Alzheimer disease (FAD) mutation of presenilin 1 (PS1).
The Journal of biological chemistry - 24 Feb 2006
Tanemura Kentaro, Chui Du-Hua, Fukuda Tetsuya, Murayama Miyuki, Park Jung-Mi, Akagi Takumi, Tatebayashi Yoshitaka, Miyasaka Tomohiro, Kimura Tetsuya, Hashikawa Tsutomu, Nakano Yuka, Kudo Takashi, Takeda Masatoshi, Takashima Akihiko
Abstract excerpt
Mutations in the presenilin 1 (PS1) gene are responsible for the early onset of familial Alzheimer disease (FAD). Accumulating evidence shows that PS1 is involved in gamma-secretase activity and that FAD-associated mutations of PS1 commonly accelerate Abeta(1-42) production, which causes Alzheimer disease (AD). Recent studies suggest, however, that PS1 is involved not only in Abeta production but also in other...
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