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Article

Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jul 1999

Weihl C C, Ghadge G D, Kennedy S G, Hay N, Miller R J, Roos R P

Abstract excerpt

Most early onset cases of familial Alzheimer's disease (AD) are caused by mutations in presenilin-1 (PS1) and presenilin-2 (PS2). These mutations lead to increased beta-amyloid formation and may induce apoptosis in some model systems. Using primary cultured hippocampal neurons (HNs) and rat pheochromocytoma (PC12) cells transiently transfected with replication-defective recombinant adenoviral vectors expressing...

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PMID: 10377346
PMCID: PMC6782321

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB.PMID 10377346Read ↗

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