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Article

The role of beta-catenin stability in mutant PS1-associated apoptosis.

Neuroreport - 20 Aug 1999

Weihl C C, Miller R J, Roos R P

Abstract excerpt

Most early onset cases of familial Alzheimer's disease (FAD) are caused by mutations in presenilin-1 (PS1) and presenilin-2 (PS2). These mutations lead to increased beta-amyloid formation and induce apoptosis when expressed in vitro. Recently, PS1 has been reported to associate with beta-catenin, an armadillo repeat protein. PS1 may regulate the function of beta-catenin, and mutant PS1 may disrupt this...

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Identifiers

PMID: 10574364
DOI: 10.1097/00001756-199908200-00017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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