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Article

Phosphatidic acid is a pH biosensor that links membrane biogenesis to metabolism.

Science (New York, N.Y.) - 27 Aug 2010

Young Barry P, Shin John J H, Orij Rick, Chao Jesse T, Li Shu Chen, Guan Xue Li, Khong Anthony, Jan Eric, Wenk Markus R, Prinz William A, Smits Gertien J, Loewen Christopher J R

Abstract excerpt

Recognition of lipids by proteins is important for their targeting and activation in many signaling pathways, but the mechanisms that regulate such interactions are largely unknown. Here, we found that binding of proteins to the ubiquitous signaling lipid phosphatidic acid (PA) depended on intracellular pH and the protonation state of its phosphate headgroup. In yeast, a rapid decrease in intracellular pH in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20798321
DOI: 10.1126/science.1191026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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