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The stability of the Opi1p repressor for phospholipid biosynthetic gene expression in Saccharomyces cerevisiae is dependent on its interactions with Scs2p and Ino2p.

Biochemical and biophysical research communications - 26 Nov 2024

Oshima Ayaka, Joho Ayu, Kuwahara Masako, Kagiwada Satoshi

Abstract excerpt

The yeast Saccharomyces cerevisiae Opi1p negatively regulates phospholipid biosynthetic genes. Under derepressing conditions, Opi1p binds to the endoplasmic reticulum/nuclear membrane with the aid of the membrane protein Scs2p and phosphatidic acids under derepressing conditions. Under repressing conditions, it enters the nucleus to inhibit the positive transcription factors Ino2p and Ino4p. While the spatial...

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PMID: 39432922
DOI: 10.1016/j.bbrc.2024.150849

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