Article
Interaction between repressor Opi1p and ER membrane protein Scs2p facilitates transit of phosphatidic acid from the ER to mitochondria and is essential for INO1 gene expression in the presence of choline.
The Journal of biological chemistry - 10 Nov 2017
Gaspar Maria L, Chang Yu-Fang, Jesch Stephen A, Aregullin Manuel, Henry Susan A
Abstract excerpt
In the yeast Saccharomyces cerevisiae, the Opi1p repressor controls the expression of INO1 via the Opi1p/Ino2p-Ino4p regulatory circuit. Inositol depletion favors Opi1p interaction with both Scs2p and phosphatidic acid at the endoplasmic reticulum (ER) membrane. Inositol supplementation, however, favors the translocation of Opi1p from the ER into the nucleus, where it interacts with the Ino2p-Ino4p complex,...
Topics
- Biological Transport
- Cardiolipins
- Cell Nucleus
- Choline
- Endoplasmic Reticulum
- Gene Deletion
- Gene Expression Regulation, Bacterial
- Green Fluorescent Proteins
- Lipid Droplets
- Lipid Metabolism
- Membrane Proteins
- Mitochondrial Membranes