Article
Low serum transferrin levels in HFE C282Y homozygous subjects are associated with low CD8(+) T lymphocyte numbers.
Blood cells, molecules & diseases - 1 Jan 2000
Macedo M Fatima, Cruz Eugenia, Lacerda Rosa, Porto Graça, de Sousa Maria
Abstract excerpt
Hereditary hemochromatosis (HH) is a genetic iron overload disease, in the majority of cases associated with homozygosity for the C282Y mutation of the HFE gene. In spite of this genetic homogeneity, there is a great clinical heterogeneity among HH patients. Low CD8(+) lymphocyte numbers have been associated with a more severe expression of iron overload in HH patients, and in experimental models of iron...
Topics
- Adult
- CD8-Positive T-Lymphocytes
- Female
- Genotype
- Hemochromatosis
- Hemochromatosis Protein
- Histocompatibility Antigens Class I
- Homozygote
- Humans
- Iron
- Lymphocyte Count
- Male
- Membrane Proteins
- Middle Aged
- Mutation
- Transferrin