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Article

Low serum transferrin levels in HFE C282Y homozygous subjects are associated with low CD8(+) T lymphocyte numbers.

Blood cells, molecules & diseases - 1 Jan 2000

Macedo M Fatima, Cruz Eugenia, Lacerda Rosa, Porto Graça, de Sousa Maria

Abstract excerpt

Hereditary hemochromatosis (HH) is a genetic iron overload disease, in the majority of cases associated with homozygosity for the C282Y mutation of the HFE gene. In spite of this genetic homogeneity, there is a great clinical heterogeneity among HH patients. Low CD8(+) lymphocyte numbers have been associated with a more severe expression of iron overload in HH patients, and in experimental models of iron...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16140024
DOI: 10.1016/j.bcmd.2005.08.001

Genes

HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Low serum transferrin levels in HFE C282Y homozygous subjects are associated with low CD8(+) T lymphocyte numbers.PMID 16140024Read ↗

Clinical and genetic heterogeneity in hereditary haemochromatosis: association between lymphocyte counts and expression of iron overload.Semantic proximity Read ↗

A study of 82 extended HLA haplotypes in HFE-C282Y homozygous hemochromatosis subjects: relationship to the genetic control of CD8+ T-lymphocyte numbers and severity of iron overload.Semantic proximity Read ↗

Iron loading in HFE p.C282Y homozygotes found by population screening: relationships to HLA-type and T-lymphocyte subsets.Semantic proximity Read ↗

Iron transport in a lymphoid cell line with the hemochromatosis C282Y mutation.Semantic proximity Read ↗

HFE genotype and parameters of iron metabolism in German first-time blood donors - evidence for an increased transferrin saturation in C282Y heterozygotes.Semantic proximity Read ↗

T-cell receptor repertoire in hereditary hemochromatosis: a study of 32 hemochromatosis patients and 274 healthy subjects.Semantic proximity Read ↗

Relative impact of HLA phenotype and CD4-CD8 ratios on the clinical expression of hemochromatosis.Semantic proximity Read ↗

Involvement of the major histocompatibility complex region in the genetic regulation of circulating CD8 T-cell numbers in humans.Semantic proximity Read ↗

Phenotypic expression in detected C282Y homozygous women depends on body mass index.Semantic proximity Read ↗

Haematological effects of the C282Y HFE mutation in homozygous and heterozygous states among subjects of northern and southern European ancestry.Semantic proximity Read ↗

Effects of highly conserved major histocompatibility complex (MHC) extended haplotypes on iron and low CD8+ T lymphocyte phenotypes in HFE C282Y homozygous hemochromatosis patients from three geographically distant areas.Semantic proximity Read ↗

A new 500 kb haplotype associated with high CD8+ T-lymphocyte numbers predicts a less severe expression of hereditary hemochromatosis.Semantic proximity Read ↗

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