Article
Sphingosine-1-phosphate plays a role in the suppression of lateral pseudopod formation during Dictyostelium discoideum cell migration and chemotaxis.
Cell motility and the cytoskeleton - 1 Dec 2004
Kumar Akhilesh, Wessels Deborah, Daniels Karla J, Alexander Hannah, Alexander Stephen, Soll David R
Abstract excerpt
Sphingosine-1-phosphate (S-1-P) is a bioactive lipid that plays a role in diverse biological processes. It functions both as an extracellular ligand through a family of high-affinity G-protein-coupled receptors, and intracellularly as a second messenger. A growing body of evidence has implicated S-1-P in controlling cell movement and chemotaxis in cultured mammalian cells. Mutant D. discoideum cells, in which the...
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