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Article

Msx1-deficient mice fail to form prosomere 1 derivatives, subcommissural organ, and posterior commissure and develop hydrocephalus.

Journal of neuropathology and experimental neurology - 1 Jun 2004

Fernández-Llebrez P, Grondona J M, Pérez J, López-Aranda M F, Estivill-Torrús G, Llebrez-Zayas P F, Soriano E, Ramos C, Lallemand Y, Bach A, Robert B

Abstract excerpt

Msx1 is a regulatory gene involved in epithelio-mesenchymal interactions in limb formation and organogenesis. In the embryonic CNS, the Msx1 gene is expressed along the dorsal midline. Msx1 mutant mice have been obtained by insertion of the nlacZ gene in the Msx1 homeodomain. The most important features of homozygous mutants that we observed were the absence or malformation of the posterior commissure (PC) and of...

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Identifiers

PMID: 15217086
DOI: 10.1093/jnen/63.6.574

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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