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Article

Generation and analysis of Brca1 conditional knockout mice.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2004

Deng Chu-Xia, Xu Xiaoling

Abstract excerpt

Germline mutations of the breast tumor suppressor gene BRCA1 predispose women to breast and ovarian cancers. However, loss-of-function mutations of mouse Brca1 results in recessive embryonic lethality, which obscures the functions of BRCA1 in breast cancer formation. Cre-loxP-mediated tissue-specific knockout was employed to overcome this obstacle. We found that the presence of a ploxP-neo-loxP cassette in intron...

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Source

Identifiers

PMID: 15187254
DOI: 10.1385/1-59259-788-2:185

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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