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Article

Malarone treatment failure not associated with previously described mutations in the cytochrome b gene.

1 Jan 2004

Abstract excerpt

Malarone (atovaquone-proguanil) is an effective drug for the treatment and prophylaxis of multidrug-resistant falciparum malaria. However, first cases of resistance have been reported, which are associated with mutations at codon 268 of the parasite's cytochrome b gene. We report the first case of Malarone treatment failure from Central Africa.Drug concentration was well within curative range. Pre- and...

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PMID: 15186499
DOI: 10.1186/1475-2875-3-14

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