Article
Detection of atovaquone-proguanil resistance conferring mutations in Plasmodium falciparum cytochrome b gene in Luanda, Angola.
Malaria journal - 5 Apr 2006
Pimentel Sónia, Nogueira Fátima, Benchimol Carla, Quinhentos Vatúsia, Bom Joana, Varandas Luís, do Rosário Virgílio, Bernardino Luís
Abstract excerpt
BACKGROUND: The fixed dose combination atovaquone-proguanil is a recently introduced antimalarial for treatment and prophylaxis of Plasmodium falciparum malaria. It is highly effective with a good tolerability profile and a convenient prophylactic regimen. Nevertheless, cases of treatment failure have already been reported, which have been associated to mutations in the cytochrome b gene of the Plasmodium...
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