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Article

Clinical implications of Plasmodium resistance to atovaquone/proguanil: a systematic review and meta-analysis.

The Journal of antimicrobial chemotherapy - 1 Mar 2018

Staines Henry M, Burrow Rebekah, Teo Beatrix Huei-Yi, Chis Ster Irina, Kremsner Peter G, Krishna Sanjeev

Abstract excerpt

Background: Atovaquone/proguanil, registered as Malarone®, is a fixed-dose combination recommended for first-line treatment of uncomplicated Plasmodium falciparum malaria in non-endemic countries and its prevention in travellers. Mutations in the cytochrome bc1 complex are causally associated with atovaquone resistance. Methods: This systematic review assesses the clinical efficacy of atovaquone/proguanil...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29237012
DOI: 10.1093/jac/dkx431
PMCID: PMC5890752

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Clinical implications of Plasmodium resistance to atovaquone/proguanil: a systematic review and meta-analysis.PMID 29237012Read ↗

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Mutations in Plasmodium falciparum cytochrome b that are associated with atovaquone resistance are located at a putative drug-binding site.Semantic proximity Read ↗

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